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Dysfibrinogenemia Functional Panel


Panel for the assessment of fibrinogen function and . Thrombin time may be prolonged due to afibrinogenemia, hypofibrinogenemia, dysfibrinogenemia, or the presence of heparin and direct thrombin inhibitors. Heparin contamination can be ruled out by adding protamine sulfate if thrombin time is prolonged.

STAT: < 24 hours (7 days a week)


Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma Three aliquots, 1mL each Three aliquots, 0.5mL each Room Temp.: 2 hours
Refrigerated: 2 hours
Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample

General Information

STAT TAT < 24 hours (7 days a week)
STAT TAT Performance > 90% of results released in 24 hours 7 days a week
ROUTINE TAT < 1 week
ALTERNATIVE NAMES Fibrinogen panel
DESCRIPTION The clot-based and ELISA-based tests in this panel are designed to be sensitive to fibrinogen disorders including dysfibrinogenemia, hypofibrinogenemia, hypodysfibrinogenemia and afibrinogenemia. In order to confirm the absence of heparins or DTIs, the thrombin time test reflexes to a heparin neutralization test when prolonged.
NORMAL RANGE Interpretation: Normal

1. Medved L et al. Fibrinogen and Factor XIII Subcommittee of Scientific Standardization Committee of International Society on Thrombosis and Haemostasis. Recommendations for nomenclature on fibrinogen and fibrin. J Thromb Haemost 2009; 7:355.

2. Tennent GA et al. Human plasma fibrinogen is synthesized in the liver. Blood 2007; 109:1971.

3. Martinez J. Congenital dysfibrinogenemia. Curr Opin Hematol 1997; 4:357.

4. Collen D et al. Metabolism and distribution of fibrinogen. I. Fibrinogen turnover in physiological conditions in humans. Br J Haematol 1972; 22:681.

SAMPLE REPORT Upon request

Test Codes

CPT CODE 85730, 85384, 85610, 85670
LOINC CODE 3255-7, 3243-3, 14979-9, 5902-2, 6301-6