Protein S Antigen (Total) - Machaon Diagnostics

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Protein S Antigen (Total)

Justification

Reduced protein S may be seen in warfarin therapy, pregnancy, use of oral contraceptives, DIC, acute thrombosis, HIV, nephrotic syndrome, liver disease and L-asparaginase chemotherapy. Congenital or acquired deficiency of protein S is also a risk factor for venous thromboembolism (VTE). Protein S is a vitamin K-dependent glycoprotein, and therefore it is reduced in patients stabilized on warfarin. Protein S is a cofactor for activated protein C, which inactivates procoagulant factors Va and VIIIa, thereby reducing thrombin generation. Protein S is also a cofactor for activated protein C in enhancing fibrinolysis. Free protein S measurement may be superior to functional protein S measurement in patients that have not been screened for the absence of the factor V Leiden (FVL) mutation.

STAT: < 1 week

ELISA

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

	Sample Type	Volume Required	Minimum Volume	Stability
PREFERRED	Citrated Plasma	1mL	0.5mL	Room Temp.: 2 hours Refrigerated: 2 hours Frozen (-20C): 2 weeks Frozen (-80C): 6 months
ALTERNATIVE	-	-	-	-

REJECTION CRITERIA	Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS	-

General Information

METHODOLOGY	ELISA
STAT TAT	< 1 week
STAT TAT Performance	> 90% of results released in 1 week
ROUTINE TAT	< 1 week
ALTERNATIVE NAMES	PS Total
DESCRIPTION	-
LIMITATIONS	-
NORMAL RANGE	-
ASSOCIATED TESTING	-
REFERENCES	-
SAMPLE REPORT	Upon request
NEW YORK STATE APPROVED	-

Test Codes

ORDER CODE	P3102
CPT CODE	85305
LOINC CODE	27823-4