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Lupus Anticoagulant Panel

Justification

LAs are heterogeneous IgG autoantibodies that bind to phospholipids. LAs are identified by their ability to prolong clot-based assays that have reduced reagent phospholipid. This comprehensive panel employs two clot-based assays, a lupus-sensitive aPTT and dilute Russell Viper Venom time, and an antibody assay, Anticardiolipin Antibody (IgG, IgM, IgA), to screen for the presence of a lupus anticoagulant, along with additional confirmatory tests, including Thrombin Time, a Lupus Anticoagulant Index, an aPTT-LA mixing study, and Prothrombin Time. Lupus anticoagulant antibodies increase the risk of arterial thrombosis, venous thrombosis, thrombocytopenia and recurrent miscarriage.

Panel Component Tests

aPTT-LA (Lupus Sensitive) Russell Viper Venom Time (dilute) Anticardiolipin Antibody (IgG, IgM, IgA) Thrombin Time aPTT-LA Mixing Studies (Lupus Sensitive) Lupus Anticoagulant Index Prothrombin Time (PT/INR)

STAT: < 48 hours (M-F)

Clot-based, CIA

Draw Tube: Blue Top

Draw Tube: Red Top

Sample Type: Citrated Plasma and Serum

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma and Serum Three aliquots, 1mL each (Citrated Plasma);One aliquot, 1mL (Serum) Three aliquots, 0.5mL each (Citrated Plasma);One aliquot, 0.5mL (Serum) Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Clot-based, CIA
STAT TAT < 48 hours (M-F)
STAT TAT Performance > 90% of results released in 48 hours
ROUTINE TAT < 1 week
ALTERNATIVE NAMES LA Panel, LAP
DESCRIPTION Machaon’s Lupus Anticoagulant (LA) Algorithm is based on College of American Pathologist (CAP) and International Society on Thrombosis and Haemostasis (ISTH) published LA detection guidelines.
LIMITATIONS -
NORMAL RANGE Interpretation: Normal
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED -

Test Codes

ORDER CODE P1183
CPT CODE 86147x3, 85730, 85613
LOINC CODE 3181-5, 3182-3, 5076-5, 34571-0, 6303-2