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Factor VIII (8) Inhibitor Titer

Justification

Acquired factor deficiencies may occur due to the development of factor-specific inhibitory antibodies. These antibodies may also develop against factor replacement products in patients with a congenital deficiency. This test may be used to detect and quantitate inhibitory antibodies against Factor VIII.

STAT: < 24 hours (M-F)

Bethesda, Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma Two aliquots, 1mL each Two aliquots, 0.5mL each Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Bethesda, Clot-based
STAT TAT < 24 hours (M-F)
STAT TAT Performance > 90% of results released in 24 hours 7 days a week
ROUTINE TAT < 3 days (M-F)
ALTERNATIVE NAMES Anti-Hemophilic Factor inhibitor, F8 inhibitor, FVIII inhibitor, clottable F8 inhibitor
DESCRIPTION Bethesda titer for the quantitative determination of a specific factor inhibitor against factor VIII (8).
LIMITATIONS -
NORMAL RANGE < 0.4 BU
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED No

Test Codes

ORDER CODE P3071
CPT CODE 85240, 85335
LOINC CODE 3210-2