Factor V (5) Activity - Machaon Diagnostics

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Factor V (5) Activity

Justification

In its active form, Factor V is a cofactor, which together with activated Factor X, forms a prothrombinase complex that more efficiently converts prothrombin to thrombin than FXa alone. Congenital deficiency of Factor V leads to Owren’s disease (or parahemophilia), a rare inherited disorder that causes mild to severe bleeding. Deficiencies in Factor V activity may also be acquired secondary to other diseases such as liver disease, disseminated intravascular coagulation (DIC), or the development of a specific factor inhibitor.

STAT: < 24 hours (7 days a week)

Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

	Sample Type	Volume Required	Minimum Volume	Stability
PREFERRED	Citrated Plasma	1mL	0.5mL	Frozen (-20C): 2 weeks Frozen (-80C): 6 months
ALTERNATIVE	-	-	-	-

REJECTION CRITERIA	Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS	-

General Information

METHODOLOGY	Clot-based
STAT TAT	< 24 hours (7 days a week)
STAT TAT Performance	> 90% of results released in 24 hours 7 days a week
ROUTINE TAT	< 3 days (M-F)
ALTERNATIVE NAMES	Proaccelerin, Labile Factor, F5, FV
DESCRIPTION	This is a clot-based assay for the determination of Factor V Activity level in citrated plasma. Patient sample at three different dilutions is mixed with Factor V Deficient plasma containing normal levels of all other factors, such that the resulting Prothrombin Time is dependent only on the level of Factor V present in the patient sample. This value is compared to a reference curve generated from calibrators with known levels of Factor V Activity.
LIMITATIONS	-
NORMAL RANGE	66-150%
ASSOCIATED TESTING	-
REFERENCES	-
SAMPLE REPORT	Upon request
NEW YORK STATE APPROVED	No

Test Codes

ORDER CODE	P3049
CPT CODE	85220
LOINC CODE	3193-0