Factor IX (9) Activity - Machaon Diagnostics

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Factor IX (9) Activity

Justification

Factor IX (Christmas Factor) is synthesized by the liver and is vitamin K-dependent. Hemophilia B is characterized by a congenital deficiency of Factor IX, and inherited in an X-linked recessive manner. The severity of the disorder depends on the Factor IX level: <1% (severe hemophilia), 1-5% (moderate hemophilia), 5-25% (mild hemophilia). Deficiencies in Factor IX may also be acquired secondary to other diseases such as liver disease, disseminated intravascular coagulation (DIC), vitamin K deficiency, or the development of a specific factor inhibitor.

STAT: < 24 hours (7 days a week)

Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

	Sample Type	Volume Required	Minimum Volume	Stability
PREFERRED	Citrated Plasma	1mL	0.5mL	Frozen (-20C): 2 weeks Frozen (-80C): 6 months
ALTERNATIVE	-	-	-	-

REJECTION CRITERIA	Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS	-

General Information

METHODOLOGY	Clot-based
STAT TAT	< 24 hours (7 days a week)
STAT TAT Performance	> 90% of results released in 24 hours 7 days a week
ROUTINE TAT	< 3 days (M-F)
ALTERNATIVE NAMES	Christmas Factor, antihemophilic factor B, plasma thromboplastin component, F9, FIX
DESCRIPTION	This is a clot-based assay for the determination of Factor IX Activity level in citrated plasma. Patient sample at three different dilutions is mixed with Factor IX Deficient plasma containing normal levels of all other factors, such that the resulting activated Partial Thromboplastin Time is dependent only on the level of Factor IX present in the patient sample. This value is compared to a reference curve generated from calibrators with known levels of Factor IX Activity.
LIMITATIONS	-
NORMAL RANGE	88-150%
ASSOCIATED TESTING	-
REFERENCES	-
SAMPLE REPORT	Upon request
NEW YORK STATE APPROVED	No

Test Codes

ORDER CODE	P3054
CPT CODE	85250
LOINC CODE	3187-2