aHUS & HLH Genetics in 48 hours

Coagulation, Platelets, Rare Disease & Genetics
HomeaHUS & HLH Genetics in 48 hours
aHUS & HLH Genetics in 48 hours

aHUS & HLH Testing at Machaon

Trusted Expertise


Atypical hemolytic uremic syndrome (aHUS) is a life-threatening, progressive, genetic disease currently diagnosed clinically by excluding other diseases. 50% of patients diagnosed with aHUS will die, develop end-stage renal disease (ESRD) or suffer permanent kidney injury within the 1 year of diagnosis despite plasma exchange (PE) or plasma infusion (PI) therapy. aHUS most frequently occurs following some triggering event (transplantation, pregnancy, malignant hypertension, autoimmune disorders, sepsis, malignancy, others) revealing a defect in the complement regulatory system. aHUS presents with clinical features nearly identical to thrombotic thrombocytopenic purpura (TTP) and HUS, making immediate laboratory differentiation essential.

Hemophagocytic Lymphohistiocytosis (HLH) is a life-threatening disease where an underlying immune defect and/or triggering event initiates excessive activation of immune cells (macrophages and lymphocytes) leading to multi-organ dysfunction and failure. Treatment of HLH may vary depending on the underlying cause, including whether a genetic cause is detected. Timely diagnosis has been a major challenge, with patients having to start aggressive therapies or be admitted to the ICU before final diagnostic results are available. Note: this is the third time (3.0 name designation) we have updated the gene list to reflect the most current understanding of HLH in the scientific literature.


  • Coagulation & Platelet Disorders
  • Complement-mediated Diseases
  • Immunology
  • Rare Diseases
  • Kidney Diseases
  • Comprehensive Genetics


  • 80% of staff are MD, PhD, CLS, MS or professionally licensed
  • 600+ years of aggregate specialized laboratory experience
  • 50% of CLS staff are trained CAP laboratory inspectors
Our Mission

To save more lives with lab tests

Our Vision

To lead the healthcare industry in rapid, clinically meaningful, innovative laboratory solutions

Our Values

Integrity, Quality, Solutions-Oriented, Constantly Improving Service

Our Process

Delivering high-quality services with the fastest-in-the-nation speed

Delivering results when they matter most.
“We are VERY happy; Great job in getting out the ADAMTS13 level & inhibitor screen! We are VERY happy – great quality results and turnaround time. Love the interpretive comments. Thanks – good job!”
MD, Chair, Pediatric Neurosurgery
Chapel Hill, NC

9 out of 10 Top Medical Centers Choose Machaon

CRO and Testings United Under One Umbrella

The majority of premier medical centers (according to US News) rely on Machaon Diagnostics to provide critical diagnostic services.

Why Machaon?

  • Usually the Fastest STAT TAT in the Industry
  • Expansive Specialized Tests
  • Lab Testing and CRO Services United Under One Umbrella
  • Customer First Approach

Who Else is Choosing Machaon?

  • 8 out of the 10 largest global pharmaceutical companies
  • 8 out of the 10 largest global CROs
From CLS to CEO, the Story of Machaon Diagnostics
Blood, Sweat & Smears®: The Machaon Podcast

In this episode we hear an interview with Mike Ero, Machaon Diagnostics’ Founder and CEO. A Clinical Laboratory Scientist (CLS) who added an MBA, Mike started Machaon Diagnostics back in 2003 at the age of 29. Just how did all of that come about? Listen and find out.



Unparalleled Service

Savings More Lives with Lab Tests

We have rapidly grown into a group of pathologists, scientists, consultants and technologists dedicated to saving lives through testing. Collectively, the Machaon Diagnostics team brings over 600 years of combined expertise to the field of laboratory medicine. 


  • CAP & CLIA-accredited
  • Multi-state licensed
  • Minority Business Enterprise (MBE)
  • GCLP-certified staff


  • CAP, CLIA & State Compliant SOPs
  • GCP & GLP-compliant Study Design
  • GDPR-compliant Trial Design
  • IVDR Projects

Papilio Machaon

Papilio Machaon (Old World Swallowtail Butterfly)

Over the last 20 years we have transformed from an esoteric coagulation laboratory to advanced hemostasis, complement, genetics and rare disease Lab/CRO

Our Goal: Fastest in the Industry

with high quality results

The faster a physician can get a lab result, the better it is for the patient. This golden rule of lab medicine is often the difference between life and death.

Machaon Diagnostics only offers a test if we can consistently achieve the fastest STAT TAT in the industry.


  • TAT performance shared with clients
  • Test progression monitoring
  • Realtime courier monitoring
  • 95% TAT confidence intervals measured


  • SMS text alerts on critical lab results
  • Critical results called (with verbal read back)
  • Genetic counseling
  • MD/CLS consultations

Machaon Highlights

  • Founded in 2003 by a clinical laboratory scientist (CLS)
  • 2 CAP/CLIA sites
  • 80% of staff are MD, PhD, CLS, MS or professionally licensed
  • 50% of our CLS staff are trained CAP inspectors
  • CA medical director is a key opinion leader in TMAs, benign hematology disorders and kidney diseases
  • Louisiana medical director is a nationally recognized pathology expert in thrombosis and hemostasis
  • Existing relationships with hospital systems in 50 states and 20 countries
  • Clients include small, medium and large pharma, biotech, CROs for local to global studies