IL-18 Level - Machaon Diagnostics
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IL-18 Level

Justification

IL-18 is a marker of monocyte-related inflammation and is commonly used to characterize hyperinflammation syndromes, where elevations are associated with HLH, MAS and other hyperinflammatory syndromes. This test can measure levels of IL-18 up to 117,120pg/mL. Ordering the extended version of this test (see standard order form) is required to detect levels above 117,120pg/mL.

STAT: < 24 hours (7 days a week)

Automated ELISA

Draw Tube: Purple Top

Sample Type: EDTA plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED EDTA plasma 1mL 0.5mL Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS None

General Information

METHODOLOGY Automated ELISA
STAT TAT < 24 hours (7 days a week)
STAT TAT Performance > 95% of STAT results released in 24 hours
ROUTINE TAT < 48 hours (Monday-Friday)
ALTERNATIVE NAMES IL18, Interleukin-18, Total IL-18
DESCRIPTION Chromogenic ELISA for the quantitative determination of IL-18.
LIMITATIONS Grossly hemolyzed samples are not suitable for use in this assay. The extent of interference from lipemia and icterus is unknown.
NORMAL RANGE 82-344pg/mL
ASSOCIATED TESTING sIL-2R, CXCL9, HLH Genetic Panel
REFERENCES
  1. Krei JM, Møller HJ, Larsen JB. The role of interleukin-18 in the diagnosis and monitoring of hemophagocytic lymphohistiocytosis/macrophage activation syndrome – a systematic review. Clin Exp Immunol. 2021 Feb;203(2):174-182.
  1. Ihim SA, Abubakar SD, Zian Z, Sasaki T, Saffarioun M, Maleknia S, Azizi G. Interleukin-18 cytokine in immunity, inflammation, and autoimmunity: Biological role in induction, regulation, and treatment. Front Immunol. 2022 Aug;11(13):919973. doi: 10.3389/fimmu.2022.919973.
  1. Jordan MB, et al. Blood. 2011;118(15):4041.
SAMPLE REPORT Inquire
NEW YORK STATE APPROVED Yes

Test Codes

ORDER CODE P3428
CPT CODE 83520
LOINC CODE 33823-6