Terms & Conditions

Welcome to MachaonDiagnostics.com (the “Site”). Please read these terms and conditions carefully. By accessing or using the Site, you are agreeing to these Terms of Use. The provision of information and services on this Site by the owners and operators of MachaonDiagnostics.com is subject to your agreement to the terms and conditions below.

1. Scope of Terms

These terms of use apply to your use of our www.MachaonDiagnostics.com Web site (the Site). The Site is owned and operated by Machaon Diagnostics Incorporated (Machaon Diagnostics).

2. Disclaimer Content

This Site provides information about our company and its products and services, including diagnostic health testing and services, data analysis, clinical trials capabilities, employer health management solutions, and information about various health conditions.

The clinical information contained within this Site is intended for the use of health care professionals. Healthcare professionals should exercise their own clinical judgment when using our content, tools or databases.

If you are a patient or health care consumer, you should not use information found on this Site to replace a relationship with your physician or other healthcare professional and should not rely on that information as professional medical advice. Always seek the advice of your physician or other qualified health care provider concerning questions you have regarding a medical condition, and before starting, stopping, or modifying any treatment or medication. In the case of a health emergency, seek immediate assistance from emergency personnel. Never delay obtaining medical advice or disregard medical advice because of something you have or have not read on this Site.

The information (including, without limitation, advice and recommendations) and services on this Site are intended solely as a general educational aid and are neither medical nor health care advice for any individual problem nor a substitute for medical or other professional advice and services from a qualified health care provider familiar with your medical history. Use of this Site does not create a doctor-patient relationship. No information contained in this Site is intended to be used for medical diagnosis or treatment.

While Machaon Diagnostics attempts to keep all the information on this Site up-to-date, medical treatment and knowledge change quickly, and this Site should not be considered error-free or as a comprehensive source of all information on a particular topic. Machaon Diagnostics makes no warranties or representations as to the accuracy of the content of this Site, and assumes no responsibility for any consequences relating directly or indirectly to any action or inaction you take based upon the information and material on this Site. Your use of this Site is subject to the additional disclaimers and caveats that may appear throughout these terms and conditions and the Machaon Diagnostics Site. You assume the entire risk of loss in using this Site and materials contained in the Site.

Features and specifications of products or services described or depicted on this Site are subject to change at any time without notice.

3. Copyright, Trademarks and other Intellectual Property

Copyright, trademark, patent, and other applicable laws protect the services and materials appearing on this Site. All materials on this Site may be accessed, downloaded or printed for the noncommercial purpose of scientific or educational advancement or within the scope allowable by these terms and conditions. No other use of these materials may be made without express written permission of the operators of Machaon Diagnostics. Any unauthorized use of the words or images on this Site may violate copyright laws, trademark laws, the laws of privacy and publicity, and civil and criminal statutes.

This Site includes material that is derived in whole or in part from materials that are copyrighted, including the format and layout of the Site. The copyrights are owned by Machaon Diagnostics, or for licensed content, the content providers.

www.Machaon Diagnostics.com is owned by Machaon Diagnostics Incorporated. None of the names, trademarks, service marks and logos of Machaon Diagnostics appearing on this Site may be used in any advertising or publicity, or otherwise to indicate Machaon Diagnostics’ sponsorship of or affiliation with any product or service, without express written permission of the operators of Machaon Diagnostics. Nothing contained on this Site should be construed as granting, by implication, estoppel, waiver or otherwise, any license or right of use to any trademark displayed on the Site without the written permission of the owners and operators of Machaon Diagnostics or the third party owner of the trademark, if any. This Site may contain other proprietary notices and copyright information, the terms of which must be observed and followed.

4. Right to Change Terms and Conditions

Machaon Diagnostics may, at any time and from time to time, change these terms and conditions. Any changes to these terms and conditions will be effective immediately upon posting of the changed terms and conditions on this Site. You agree to review these terms and conditions periodically, and use of the Site following any such change constitutes your agreement to follow and be bound by the terms and conditions as changed.

5. Links to Other Sites

This Site may contain third party-owned content (e.g., articles, data feeds, abstracts, etc.) and may also include hypertext links to third party-owned web sites. We provide such third party content and links as a courtesy to our users. We have no control over any third party-owned web sites or content referenced, accessed by or available on this Site and, therefore, we do not endorse, sponsor, recommend or otherwise accept any responsibility for such third party web sites or content or for the availability of such web sites. IN PARTICULAR, WE DO NOT ACCEPT ANY LIABILITY ARISING OUT OF ANY ALLEGATION THAT ANY THIRD PARTY-OWNED CONTENT (WHETHER PUBLISHED ON THIS, OR ANY OTHER, WEB SITE) INFRINGES THE INTELLECTUAL PROPERTY RIGHTS OF ANY PERSON OR ANY LIABILITY ARISING OUT OF ANY INFORMATION OR OPINION CONTAINED ON SUCH THIRD PARTY WEB SITE OR CONTENT. If you link to third party sites from Machaon Diagnostics, we encourage you to consult the policy statements and the terms and conditions of each site you visit.

6. Links to This Site

We welcome links to this web site. However, we do not wish to be linked to or from any third-party web site or link which contains:

  1. any information that misrepresents the nature of your relationship with our organization, or incorrect facts or data about our organization; or
  2. any unlawful, threatening, abusive, libelous, defamatory, obscene, vulgar, pornographic, profane or indecent information of any kind, including, without limitation, any content constituting or encouraging conduct that would constitute a criminal offense, give rise to civil liability or otherwise violate any local, state, provincial, national or international law, regulation which may be damaging or detrimental to the activities, operations, credibility or integrity of Machaon Diagnostics; or
  3. any material or information of any kind, which promotes racism, bigotry, hatred or physical harm of any kind against any group or individual, could be harmful to minors, harasses or advocates harassment of another person, provides material that exploits people under the age of 18 in a sexual or violent manner, provides instructional information about illegal activities, including, without limitation, the making or buying of illegal weapons; or
  4. any information, software or other material which violates or infringes upon the rights of others, including material which is an invasion of privacy or publicity rights, or which is protected by copyright, trademark or other proprietary rights.

We reserve the right to prohibit or refuse to accept any link to the web site, including, without limitation, any link which contains or makes available any content or information of the foregoing nature, at any time.

7. Advertising and Sponsorships

We do not accept paid advertisements or sponsorships on this Site.

8. Disclaimer of Warranty; Limitation of Liability

MACHAON DIAGNOSTICS DISCLAIMS ALL EXPRESS AND IMPLIED WARRANTIES WITH REGARD TO THE INFORMATION, SERVICES AND MATERIALS CONTAINED ON THIS SITE, INCLUDING, WITHOUT LIMITATION, ANY IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NON-INFRINGEMENT. YOUR USE OF THIS SITE IS AT YOUR OWN RISK. ACCESS TO THIS SITE MAY BE INTERRUPTED AND INFORMATION, SERVICES AND MATERIALS MAY NOT BE ERROR-FREE. NONE OF MACHAON DIAGNOSTICS, OR ANYONE ELSE INVOLVED IN CREATING, PRODUCING OR DELIVERING THIS SITE OR THE INFORMATION, SERVICES AND MATERIALS CONTAINED HEREIN ASSUMES ANY LIABILITY OR RESPONSIBILITY FOR THE ACCURACY, COMPLETENESS OR USEFULNESS OF ANY INFORMATION, SERVICES AND MATERIALS PROVIDED ON THIS SITE; THEY ALSO SHALL NOT BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, CONSEQUENTIAL OR PUNITIVE DAMAGES ARISING OUT OF YOUR USE OF, OR INABILITY TO USE, THIS SITE. ALL INFORMATION, SERVICES AND MATERIALS ARE PROVIDED “AS IS” AND “AS AVAILABLE” WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED.

YOU ACKNOWLEDGE AND AGREE THAT THE LIMITATIONS SET FORTH ABOVE ARE FUNDAMENTAL ELEMENTS OF THIS AGREEMENT AND THIS SITE WOULD NOT BE PROVIDED TO YOU ABSENT SUCH LIMITATIONS.

PLEASE NOTE THAT SOME JURISDICTIONS MAY NOT ALLOW THE EXCLUSION OF IMPLIED WARRANTIES, SO SOME OF THE ABOVE EXCLUSIONS MAY NOT APPLY TO YOU. CHECK YOUR LOCAL LAWS FOR ANY RESTRICTIONS OR LIMITATIONS REGARDING THE EXCLUSION OF IMPLIED WARRANTIES.

9. Web Privacy Statement

Machaon Diagnostics will treat all information submitted by you or other visitors to this Site as confidential in accordance with its privacy and security practices concerning health-related information. Our Privacy Policy also identifies the information we collect online and the steps we take to protect it.

10. Indemnification

You agree to indemnify, defend and hold harmless Machaon Diagnostics and its suppliers and their respective affiliates, employees, officers, directors, agents, servants and representatives of each from any liability, loss, claim, suit, damage, and expense (including reasonable attorneys´ fees and expenses) related to (i) your violation of these terms and conditions and (ii) your posting of material to this Site.

11. Applicable Law

These terms and conditions and the resolution of any dispute related to these terms and conditions shall be construed in accordance with the laws of the State of California. Any dispute between Machaon Diagnostics and you related to these terms and conditions shall be resolved exclusively by the state and federal courts of the State of California.

This Web Site can be accessed from the United States and other countries worldwide. Since the laws of each State or country may differ, you agree that the statutes and laws of the State of California, without regard to any principles of conflicts of law, will apply to all matters relating to the use of this Site.

Machaon Diagnostics makes no representation that material on this Site is appropriate or available for use in other locations, and accessing this information from territories where the content is illegal is prohibited. Those who choose to access the Site from other locations do so by their own initiative and are responsible for compliance with local laws.

12. Termination

These terms and conditions are effective unless and until modified as noted above, or terminated, at any time, by Machaon Diagnostics. If, in the sole discretion of Machaon Diagnostics, you fail to comply with these terms and conditions, Machaon Diagnostics may terminate these terms and conditions without notice and deny you access to the Site.

13. Contact Information

Machaon Diagnostics is headquartered in Oakland, California, in the United States of America.

Machaon Diagnostics, Inc.
3023 Summit Street
Oakland, CA 94609
Attn: Administration

Specific questions and comments should be directed to the appropriate department via our Contact Us page. While we make every effort to respond to all correspondence within 1 business week, we cannot guarantee a response to every electronic communication.

Panels
Tests
Order Forms
Collection Guide
Education and Publications
Clinical Trial Services
Patients

Panels

Panel Name STAT Turnaround Time Draw Kit Available (Y/N) Sample Requirement
PlateletGenex Functional Defect Panel 48 hours (M-F, two consecutive business days required) Yes EDTA whole blood
aHUS Genetic Panel 48 hours (M-F, two consecutive business days required) Yes EDTA whole blood
Alport Syndrome Genetic Panel 2 business days Yes EDTA whole blood
Heparin Antibody Confirmation Panel < 24 hours (M-F) Yes serum
Hypercoagulability Panel < 24 hours No citrated plasma
von Willebrand Factor Profile with Multimer < 5 days No citrated plasma
Lupus Anticoagulant Screen < 24 hours No citrated plasma
Platelet Aggregation Study – Comprehensive < 24 hours No citrated whole blood
Prolonged aPTT / PT Evaluation Panel < 24 hours No citrated plasma
Plavix Sensitivity Panel < 24 hours Yes citrated whole blood
Mild Bleeding Disorder Panel < 24 hours No citrated whole blood
Dysfibrinogenemia Panel < 24 hours No citrated plasma
Antiphospholipid Antibody Panel < 1 week Yes serum

Tests

Test Name STAT Turnaround Time Draw Kit Available (Y/N) Sample Requirement
CFH Autoantibody 48 hours Yes plasma
PFA – Screen (Platelet Function Assessment) < 24 hours No citrated whole blood
ADAMTS-13 Activity < 24 hours (7 days a week) Yes citrated plasma
ADAMTS-13 Inhibitor < 24 hours (7 days a week) Yes citrated plasma
Heparin Antibody Confirmation < 24 hours (M-F) Yes serum
Platelet Aggregation Study – Comprehensive < 24 hours No citrated whole blood
Activated Protein C – Resistance < 1 week No citrated plasma
ADAMTS-13 Antibody < 3 days Yes citrated plasma
Alpha-2 Antiplasmin Activity < 1 week No citrated plasma
Anticardiolipin Antibody (IgG, IgM, IgA) < 24 hours No serum
Antithrombin III Activity < 24 hours No citrated plasma
Antithrombin III Antigen < 1 week No citrated plasma
aPTT < 24 hours No citrated plasma
aPTT Mixing Study < 24 hours No citrated plasma
aPTT-FS (Factor Sensitive Reagent) < 24 hours No citrated plasma
aPTT-LA (Lupus Sensitive Reagent) < 24 hours No citrated plasma
aPTT-LA Mixing Study < 24 hours No citrated plasma
aPTT-FS Mixing Study < 24 hours No citrated plasma
Beta-2 Glycoprotein I Antibody (IgG, IgM, IgA) < 1 week No serum
Dabigatran (Pradaxa) Level < 24 hours No citrated plasma
Euglobulin Clot Lysis Time < 1 week No citrated plasma
Factor II (2) Activity < 24 hours No citrated plasma
Factor V (5) Activity < 24 hours No citrated plasma
Factor V (5) Leiden Gene Mutation < 24 hours No EDTA whole blood
Factor VII (7) Activity < 24 hours No citrated plasma
Factor VIII (8) Activity < 24 hours No citrated plasma
Factor IX (9) Activity < 24 hours No citrated plasma
Factor X (10) Activity < 24 hours No citrated plasma
Factor X (10) Activity – Chromogenic < 1 week No citrated plasma
Factor X (10) Antigen < 1 week No citrated plasma
Factor XI (11) Activity < 24 hours No citrated plasma
Factor XII (12) Activity < 24 hours No citrated plasma
Factor XIII (13) Activity – Quantitative < 1 week No citrated plasma
Fibrinogen Activity < 24 hours No citrated plasma
Fibrinogen Antigen < 1 week No citrated plasma
Fondaparinux (Arixtra) Level < 24 hours No citrated plasma
Heparin Antibody ELISA (reflex) < 24 hours (7 days a week) Yes serum
Heparin (LMWH) Level < 24 hours No citrated plasma
Heparin (UFH) Level < 24 hours No citrated plasma
Hexagonal Phospholipid aPTT < 1 week No citrated plasma
Homocysteine < 5 days No serum
Inhibitor Screen (aPTT Factors) < 24 hours No citrated plasma
Inhibitor Screen (PT Factors) < 24 hours No citrated plasma
Inhibitor Titer (aPTT Factors) < 24 hours No citrated plasma
Inhibitor Titer (PT Factors) < 24 hours No citrated plasma
Lupus Anticoagulant Index < 24 hours No citrated plasma
MTHFR (A1298C) Gene Mutation < 1 week No EDTA whole blood
MTHFR (C677T) Gene Mutation < 24 hours No EDTA whole blood
Plasminogen Activator Inhibitor Activity < 10 days No citrated plasma
Plasminogen Activity < 5 days No citrated plasma
Plasminogen Antigen < 5 days No citrated plasma
Platelet Electron Microscopy Study < 5 days No ACD whole blood
Platelet Antibody ID – Direct (GPIIb/IIIa, GP Ib/IX, GPIa/IIa) < 24 hours No EDTA whole blood
Platelet Antibody ID – Indirect (GPIIb/IIIa, GP Ib/IX, GPIa/IIa) < 24 hours No serum
Plavix Sensitivity – Genotype (CYP2C19 Genotyping) < 24 hours No EDTA whole blood
Aspirin Sensitivity – LTA (AA-induced Platelet Inhibition) < 24 hours No citrated whole blood
Ticagrelor Sensitivity – LTA (ADP-induced Platelet Inhibition) < 24 hours citrated whole blood
Brilinta Sensitivity – LTA (ADP-induced Platelet Inhibition) < 24 hours No citrated whole blood
Plavix Sensitivity – LTA (ADP-induced Platelet Inhibition) < 24 hours No citrated whole blood
Protein C Activity < 24 hours No citrated plasma
Protein C Antigen < 1 week No citrated plasma
Protein S Activity < 24 hours No citrated plasma
Protein S Antigen (Free) < 1 week No citrated plasma
Protein S Antigen (Total) < 1 week No citrated plasma
Prothrombin Fragment 1.2 (F1.2) < 1 week No citrated plasma
Prothrombin Gene Mutation < 24 hours No EDTA whole blood
Prothrombin Time < 24 hours No citrated plasma
PT Mixing Study < 24 hours No citrated plasma
Reptilase Clotting Time < 1 week No citrated plasma
Ristocetin Cofactor Activity < 24 hours No citrated plasma
Ristocetin-induced Platelet Aggregation < 24 hours No citrated whole blood
Rivaroxaban (Xeralto) Level < 24 hours No citrated plasma
Russell Viper Venom Time (dilute) < 24 hours No citrated plasma
Thrombin Generation (normalized-ETP) < 24 hours No citrated plasma
Thrombin Time < 24 hours No citrated plasma
Thrombin/Antithrombin Complex < 1 week No citrated plasma
Von Willebrand Factor Antigen < 24 hours No citrated plasma
Von Willebrand Factor Multimer < 5 days No citrated plasma
Warfarin Sensitivity Genotype (CYP2C9 and VKORC1) < 1 week No EDTA whole blood

Order Forms

Machaon Diagnostics has provided several downloadable documents to assist in ordering, processing and billing. Below please find links to our most frequently requested documents.

Collection Guide

Specimen processing is one of the most important aspects in the generation of accurate and reliable lab results. Many variables, such as, anticoagulant ratio, storage time and temperature, and surface of containers and drawing components can affect test results.

Machaon Diagnostics follows and recommends the use of the third edition of the National Committee for Clinical Laboratory Standards (NCCLS) guideline H21-A3: Collection, Transport, and Processing of Blood Specimens for Coagulation Testing and General Performance of Coagulation Assays.

Please contact the lab with any shipping questions

Specimen Collection

Frozen Citrated Plasma
Frozen citrated plasma is the specimen of choice for clotting assays and some ELISA testing. The anticoagulant used for these assays is 105 – 109 mmol/L, 3.13% – 3.2% of the dihydrate form of trisodium citrate (Na3C6H5O7 2H2O), buffered or nonbuffered.

Patients with hematocrit values above 55% should have their final citrate concentration corrected using the following equation:

X = (100 – PCV) / (595 – PCV) WB Volume

Where X is citrate volume required to prepare a whole blood volume (WB Volume) from a patient with a certain percent packed cell volume (PCV).

Please follow the listed suggestions for collection of citrated plasma samples.

  • A 1:9 ratio of anticoagulant to whole blood is imperative
  • Blood should be drawn directly into anticoagulant if possible
  • Syringe draws should be added to anticoagulant within 1 minute
  • Syringe draws should use no more that a 20mL volume syringe
  • A two-syringe technique is preferred for syringe draws
  • Coagulation draws should be the 2nd or 3rd tube drawn
  • Catheter draws should be avoided or under the advice of the attending physician
  • All tubes should be inverted at least 4 times to ensure adequate mixing
  • Suitable needle gauges range from 19 – 22 for coagulation and platelet testing
  • Cell-free plasma must contain less than 10,000 platelets/µL
  • Centrifugation should be performed at 1,500 × g for 15 or more minutes
  • Aliquots are frozen (<= -20ºC) promptly to minimize factor degradation
  • Specimens are shipped frozen on dry ice (-78.5ºC)

Frozen Serum
Frozen serum is the specimen of choice for most immunoglobulin detecting assays and many ELISA based tests. Whole blood is drawn into a glass or plastic tube possibly containing an activator. Please follow the tube manufacturer’s guidelines for tube handling and processing.

Please follow the listed suggestions for collection of serum samples.

  • Plastic tubes containing an activator should be inverted at least 4 times
  • Glass tubes without activator should be clotted for 2 hours at room temperature
  • Suitable needle gauges range from 19 – 22 for the serum based tests
  • Centrifugation should be performed at 1,500 × g for 15 or more minutes
  • Aliquots are frozen (<= -20ºC) before shipping and shipped on dry ice (-78.5ºC

EDTA Whole Blood
EDTA anticoagulated whole blood is the specimen of choice for molecular genetic tests.

Please follow the listed suggestions for collection of genetic samples.

  • Blood should be drawn directly into anticoagulant if possible
  • This must be a closed system draw to prevent contamination
  • All tubes should be inverted at least 4 times to ensure adequate mixing
  • Suitable needle gauges range from 19 – 22 to prevent cell lysis
  • A minimum of 2mL of whole blood is needed for genetic assays
  • No processing is required for this sample type
  • Ship this type of specimen at room temperature

Aliquoting Specimens
Submitting multiple aliquots (plasma or serum) for testing is an important aspect of clot, chromogenic and ELISA based tests. Aliquots of 1mL are requested for most of our assays. These should be frozen prior to shipment in a <= -20 C freezer or colder. Tubes should be placed into a rack to ensure the samples are frozen properly in the base of the tube. Freezing should occur within 1 hour of the time of draw. Please refer to the preferred number of aliquots when submitting samples.

Shipping

Shipment is a crucial aspect of clinical testing. Please follow the below instructions for easy shipments to the lab.

Local Shippers
Machaon Diagnostics contracts with Medical Couriers, Inc. (MCI). who service the entire San Francisco Bay Area and surrounding areas. MCI has a fleet of specially trained drivers that will visit your lab, clinic or office during specified times. Couriers carry dry ice, cold packs and room temperature containers for receipt of all specimen types.

Medical Couriers, Inc. can be phoned for individual pickup requests at the below number.

Medical Couriers, Inc.
(800)-652-1147

Place prepared samples and order forms in a shipping bag with Machaon and specimen type written in a clear and visible location.

Out-of-area Shippers
Please collect the following items:

  • Test Order Form
  • Packing material or newspaper
  • Styrofoam container, possibly with outer cardboard box
  • Packaging tape
  • Airbill for overnight shipments
  • ORM-A label for dry ice shipments (UN1845)
  • Dry ice (-78.5ºC) sufficient for transit time (5lb. per day)
  • Specimens in biohazard specimen transport bag

Packaging
Place the biohazard bag containing samples and the test order form into a Styrofoam container followed by dry ice. Fill remaining container space with packaging material and seal with packaging tape. Adhere a completed airbill and dry ice labels to the exterior of container in a visible location. Telephone your preferred overnight courier to request a pickup or place container in designated pickup area.

Please contact the lab with any shipping questions

Education and Publications

Education

Platelet Functional Defects, from the clinic to genetics (a webinar given by Dr. Brad Lewis, Feb. 24, 2017)

Diagnosing Thrombotic Microangiopathies: TTP and atypical HUS: (A Grand Rounds presentation at Mattel Children’s Hospital, UCLA, to Pediatric Nephrology with Dr. Brad Lewis.)

A guide to the video content:

00:24 – Introduction (Why we should care about diagnosis of aHUS and TTP)
1:00 – What is microangiopathic hemolytic anemia (MAHA)?
1:16 – Blood smear with schistocytes
1:40 – Von Willebrand’s protein synthesis
02:09 – ADAMTS-13 and TTP pathophysiology
02:43 – How to interpret ADAMTS-13 activity testing and advantage of doing ADAMTS-13 activity testing with Machaon Dx
03:48 – Use of ADAMTS-13 testing to diagnose “Occult” TTP
04:40 – Ruling in or out aHUS with ADAMTS-13 activity testing
05:20 – Plasma exchange for aHUS patients
05:57 – The complement cascade and aHUS pathophysiology
08:04 –aHUS patients respond to eculizumab therapy
08:45 – Unlike TTP, aHUS has triggers in 70% of cases
09:26 – aHUS is a multisystem microvascular disease (aHUS-induced organs damage)
10:09 – aHUS presentation
11:41 – Can we differentiate TTP and aHUS clinically?
12:15 – 5 reasons why you should care about aHUS patients genotyping
14:17 – Advantage of doing aHUS genetic testing with Machaon Dx
14:52 – The punchline: aHUS and TTP diagnosis algorithm

Publications

Stromsness B. et al. Perceived clinical utility of ADAMTS-13 testing decreases quickly when turnaround time extends beyond two days. Int J Lab Hematol. 2015; (abstract).

Ero M. et al. Novel variant detection is essential when attempting to genetically confirm the clinical diagnosis of complement-mediated thrombotic microangiopathies (TMA). J Clin Apheresis. 2015; (abstract O-09).

Harbert J. et al. Inhibitory effects of fish oil on platelet-associated thrombin generation as measured by the calibrated automated thrombogram: an in vitro study. Int Soc Thromb Hemost 2014; (abstract 604).

Ero M. et al. Impact of telavancin on prothrombin time and activated partial thromboplastin time as determined using point-of-care coagulometers. J Thromb Thrombolysis. 2013;38(2):235-240.

Beattie DT. Et al. An in vitro investigation of the cardiovascular effects of the 5-HT4 receptor selective agonists, Velusetrag and TD-8954. J Thromb Thrombolysis. Vascular Pharmacology. 2013;58:150–156.

Ero M. et al. A pilot study on the serum pharmacokinetics of nattokinase in humans following a single oral daily dose. Alternative Therapies. 2013;19(3): 18-21.

Higgins D. et al. The inability of tegaserod to affect platelet aggregation and coronary artery tone at supratherapeutic concentrations. Archives of Pharmacology. 2012;385(1):103-9.

Ng C. et al. Oral bioavailability of nattokinase (NSK-SD). Am J Clin Pathol. 2010;134(suppl):11.

Lakshmi P. et al. Flavocoxid, an anti-inflammatory agent of botanical origin, does not affect coagulation or interact with anticoagulation therapies. Adv Ther. 2010;27(7):1-12.

Jeske WP. et al. Isolation and characterization of heparin from tuna skins. Clin Appl Thromb Hemost. 2007 Apr;12(2):137-45.

Fareed D. et al. Nitric oxide levels are upregulated in patients with malignancy-associated hypercoagulable state. Int J Lab Hematol. 2005; (abstract).

Jeske WP. et al. A survey of venous thrombosis models. Methods Mol Med. 2004;93:221-37.

Sahud et al. von Willebrand factor-cleaving protease inhibitor in a patient with human immunodeficiency syndrome-associated thrombotic thrombocytopenic purpura. Br J Haematol. 2002; 116(4):909-911.

Fenton JW. et al. Statin drugs and dietary isoprenoids downregulate protein prenylation in signal transduction and are antithrombotic and prothrombolytic agents. Biochemistry. 2002;67(1):85-91.

Ero M. et al. Comparative effects of a novel sulfated pentamannan oligosaccaride mixture (PI-88), heparin and related agents on the tissue factor-induced platelet activation and aggregation profile in whole blood. Thromb Haemost. 2001; (abstract 6260).

Ero M. et al. An antiplatelet drug, ticlopidine, inhibits heparin-induced thrombocytopenia responses as measured by platelet aggregometry and 14C serotonin release. Thromb Haemostasis. 1997; (abstract).

Clinical Trial Services

Machaon Diagnostics provides a rapid and complete solution for companies in need of clinical trial services, contract research and independent marketing claim validation. Our team of scientists has over 100 years of clinical study expertise. Machaon Diagnostics has been performing studies on pharmaceuticals, dietary supplements, functional foods and other agents since 2003. Design, subject recruitment, sample collection/storage, testing, statistical analysis, study reporting and manuscript preparation are all included in our comprehensive service. We have an extensive database of well-characterized study volunteers, allowing us to provide some IRB-approved clinical trials in as little as 1 month. Our subject database includes normal adult, elevated risk of cardiovascular disease, high blood pressure, metabolic syndrome and other populations.

Machaon Diagnostics is a California-licensed, CLIA-accredited, College of American Pathologists (CAP)-accredited clinical laboratory authorized to provide high complexity clinical laboratory services. All laboratory testing is controlled within our Quality Assurance Program and studies are offered in a Good Laboratory Practices (GLP, 21CFR Part 58)/ EN 13612 environment.

Research & Development

Machaon Diagnostics is California’s only independent specialized coagulation lab. We are a privately owned company, staffed by CA-licensed clinical laboratory scientists under the direction of a hematologist medical director.

As a clinical lab, we provide a unique testing environment for evaluating thrombotic, fibrinolytic potential. Pharmaceutical, device and biotech compounds and materials can be studied within established, validated and controlled clinical assays with verified reference ranges. Our clinical tests are further controlled within our quality assurance and proficiency testing policies and procedures. All tests can be modified or re-designed for best-fit analysis.

Machaon Diagnostics is a California-licensed, CLIA-accredited, College of American Pathologists (CAP)-accredited clinical laboratory authorized to provide high complexity clinical laboratory services. All laboratory testing is controlled within our Quality Assurance Program and studies are offered in a Good Laboratory Practices (GLP, 21CFR Part 58)/ EN 13612 environment.

The Machaon Diagnostics laboratory facility is located on a medical center campus in Oakland, California and is staffed with over 100 years of in-house esoteric coagulation and platelet testing experience. All lab scientists are published in and passionate about the field thrombosis and hemostasis. Please contact us if we may help with your next study.

Please contact the laboratory to inquire about this service.

Assay Development

Medical procedures, devices, novel agents and methodologies must be evaluated for their impact on coagulation and platelet systems if there is suspected bleeding or clotting potential.

Our staff has had extensive experience designing unique testing systems or applying the proper testing system to answer the client’s questions quickly and accurately.

Machaon Diagnostics is a California-licensed, CLIA-accredited, College of American Pathologists (CAP)-accredited clinical laboratory authorized to provide high complexity clinical laboratory services. All laboratory testing is controlled within our Quality Assurance Program and studies are offered in a Good Laboratory Practices (GLP, 21CFR Part 58)/ EN 13612 environment.

Please contact the laboratory to inquire about this service.

Patients

What you need to know

If you are reading this page, it likely means your doctor has ordered a bleeding or clotting test for you and would like you to get this test run at Machaon Diagnostics. Machaon Diagnostics is a clinical reference lab specializing in bleeding and clotting testing, one of the few independent coagulation labs in the country. We run very specific, unique blood tests which are often critical in helping doctors determine the correct course of treatment.

Machaon Diagnostics provides specialized lab testing to hospitals and doctors all over the country and is recognized for the speed and quality of our testing.

It is important to know that your insurance may or may not cover your testing. We have a long track record of working with patients to ensure they get the testing they need and we will work with you to help find a solution should your insurance not cover the testing we would provide.

If you are coming in to Machaon for a test, here are some things you will need to have with you:

  • Your doctors lab order
  • Your insurance information
  • Your identification
  • A list of your current medications
  • If you are coming in for a Platelet Aggregation, please remember you must fast before this test.

Machaon Diagnostics was founded in 2003 and is a California-licensed, CLIA-accredited, College of American Pathologists (CAP)-accredited clinical laboratory authorized to provide high complexity clinical laboratory services. All laboratory testing is controlled within our Quality Assurance Program and studies are offered in a Good Laboratory Practices (GLP, 21CFR Part 58)/ EN 13612 environment.

Please contact the laboratory if you have questions.