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Factor II (2) Activity

Justification

Deficiencies in Factor II (Prothrombin) Activity are associated with excessive bleeding, including easy bruising, frequent nose bleeds, menorrhagia, and/or hemorrhaging during or after surgery, trauma, or childbirth. Joint bleeding is uncommon. Acquired Factor II deficiency due to coumadin anticoagulation, vitamin K deficiency, severe liver disease, or other causes is more common than congenital or inherited Factor II deficiency which is estimated to occur in 1 out of every 2 million people.

STAT: < 24 hours (7 days a week)

Clot-based

Draw Tube: Blue Top

Sample Type: Citrated Plasma

Specimen Requirements

Sample Type Volume Required Minimum Volume Stability
PREFERRED Citrated Plasma 1mL 0.5mL Room Temp.: 2 hours
Refrigerated: 2 hours
Frozen (-20C): 2 weeks
Frozen (-80C): 6 months
ALTERNATIVE - - - -
REJECTION CRITERIA Thawed in transit, refrozen or clotted sample
SPECIAL INSTRUCTIONS -

General Information

METHODOLOGY Clot-based
STAT TAT < 24 hours (7 days a week)
STAT TAT Performance > 90% of results released in 24 hours 7 days a week
ROUTINE TAT < 3 days (M-F)
ALTERNATIVE NAMES Prothrombin Activity, F2, FII
DESCRIPTION This is a clot-based assay for the determination of Factor II Activity level in citrated plasma. Patient sample at three different dilutions is mixed with Factor II Deficient plasma containing normal levels of all other factors, such that the resulting Prothrombin Time is dependent only on the level of Factor II present in the patient sample. This value is compared to a reference curve generated from calibrators with known levels of Factor II Activity.
LIMITATIONS -
NORMAL RANGE 85-142%
ASSOCIATED TESTING -
REFERENCES -
SAMPLE REPORT Upon request
NEW YORK STATE APPROVED -

Test Codes

ORDER CODE P3047
CPT CODE 85210
LOINC CODE 3289-6