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Protein C TestingProtein C: (produced by the liver via Vitamin K-dependent pathway)
Function: Inactivates the activated cofactors Va and VIIIa in the presence of co-factor, Protein S.
Acquired Deficiency:
·DIC
·Severe Liver disease
·Vitamin K deficiency
·Oral anticoagulation therapy
Testing: Protein C can be measured by clot-based (functional), chromogenic method (functional) or ELISA (antigenic).
Congenital Deficiency:
Classification of congenital deficiency
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